Sildenafil is usually a strong and selective inhibitor of cGMP-distinct phosphodiesterase type five (PDE5), which happens to be liable for degradation of cGMP within the corpus cavernosum. The molecular framework of sildenafil is similar to that of cGMP and functions being a competitive binding agent of PDE5 inside the corpus cavernosum, leading to
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aan erection that won't go away (priapism). If you have an erection that lasts over 4 hrs, get medical support at once. If it is not handled at once, priapism can forever damage your penis. sudden eyesight decline in a single or both eyes. Unexpected eyesight reduction in one or both of those eyes generally is a sign of a serious eye issue known as